Mike Webb
- Areas of expertise
- Professor Mike Webb leads the UK arm of the biological aspects of ACROPATH. Mike has extensively developed new tools for the enzymatic modification of proteins using sortase enzymes which will be a key technology for the creation of the artificial cell platform.
- Location
- UK: University of Leeds
- Website
- Webb research group
Mike is Professor of Biological Chemistry in the School of Chemistry at the University of Leeds. His research interests currently focus on the controlled modification of proteins with applications in engineering biology, biopharmaceutical development and diagnostic development. Other ongoing interests included aspects of biosynthesis, metabolism and peptide chemistry. In the ACROPATH project he leads the UK-based efforts to develop protein components of the ACROPATH sensing system.
Relevant publications:
Quantitative N- or C-Terminal Protein Labelling with Unactivated Peptides by Use of Sortases and a D-Aminopeptidase.
Arnott Z.L.P., Morgan H.E., Hollingsworth K., Stevenson C.M.E., Collins L.J., Tamasanu A., et al.
Angewandte Chemie Int Ed. (2024) 63.
DOI: 10.1002/anie.202310862
Bio-orthogonal, bifunctional linker for engineering synthetic glycoproteins.
McBerney R., Dolan J.P., Cawood E.E., Webb M.E., and Turnbull W.B.
JACS Au (2022) 2, 2038–2047.
DOI: 10.1021/jacsau.2c00312
Piggybacking on the Cholera Toxin: Identification of a Toxoid-binding Protein as an Approach for Targeted Delivery of Proteins to Motor Neurons.
Balmforth M.R., Haigh J., Kumar V., Dai W., Tiede C., Tomlinson D.C., et al.
Bioconjugate Chemistry (2021) 32 2205-2212.
DOI: 10.1021/acs.bioconjchem.1c00373